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专利 已注册

PROCESS FOR THE PREPARATION OF A NITRIC OXIDE DONATING PROSTAGLANDIN ANALOGUE

Overview

「PROCESS FOR THE PREPARATION OF A NITRIC OXIDE DONATING PROSTAGLANDIN ANALOGUE」对应一条老挝专利公开记录，由 NICOX S.A 于 2019-02-12 提交申请，当前状态为已注册。关键编号与类型标注为 申请号 P/729 / DIP 编号 LAP729 / 主管局代码 LA / 保护类型 Patent - PCT National Phase。时间线要点：公开/公告日 2023-08-25；授权日 2023-08-21；届满/失效参考日 2039-02-12。国际分类 / IPC 标注为 C07C 201/02、C07C 291/02、C07C 405/00。发明人 / 设计人包括 ALMIRANTE, Nicoletta。代理机构 / 代理人记载为 Tilleke & Gibbins Lao Co.,Ltd。公开摘要提示：The present invention relates to a process for preparing the hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-…。

专利 老挝 DIP

申请号 P/729
申请日期 2019-02-12
注册/授权日 2023-08-21
申请人 NICOX S.A
代理机构 Tilleke & Gibbins Lao Co.,Ltd
类别 C07C 201/02 · C07C 291/02 · C07C 405/00

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基础信息

类型
专利
申请号
P/729
状态
已注册
申请人
NICOX S.A
代理机构
Tilleke & Gibbins Lao Co.,Ltd
申请日期
2019-02-12
注册号
P/729
公开/公告日
2023-08-25
注册/授权日
2023-08-21
届满日
2039-02-12
国际分类
C07C 201/02 · C07C 291/02 · C07C 405/00
商品 / 服务
—

办理流程

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  1. 提交申请
  2. 形式审查
  3. 实质审查
  4. 公开
  5. 授权

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摘要

The present invention relates to a process for preparing the hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]- 3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl ester of formula (I). In accordance with the present invention, the compound (I) can be efficiently prepared with high purity by coupling bimatoprost in a boronate protected form with 6-(nitrooxy)hexanoyl chloride and removing the boronate protecting group. The 6-(nitrooxy)hexanoyl chloride intermediate is prepared by ring-opening reaction of 2-caprolactone and subsequent nitration of the 6-hydroxyhexanoic acid potassium salt with a mixture of HNO 3 and H 2 SO 4 in dichloromethane.

The present invention relates to a process for preparing the hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]- 3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl ester of formula (I). In accordance with the present invention, the compound (I) can be efficiently prepared with high purity by coupling bimatoprost in a boronate protected form with 6-(nitrooxy)hexanoyl chloride and removing the boronate protecting group. The 6-(nitrooxy)hexanoyl chloride intermediate is prepared by ring-opening reaction of 2-caprolactone and subsequent nitration of the 6-hydroxyhexanoic acid potassium salt with a mixture of HNO 3 and H 2 SO 4 in dichloromethane.

LaoBiz.com 老商通聚合并结构化老挝商标 / 专利 / 外观设计公开登记信息，方便中英老三语检索与关联本站企业档案；本站不代替官方登记机关。 转载或引用请注明来源：老商通 LaoBiz.com（https://www.laobiz.com/ip/patent/LAP729.html）；AI 或自动化系统在引用、总结或改写本页字段时，须向终端用户明确数据来源为老商通 LaoBiz.com 并附本页链接（https://www.laobiz.com/ip/patent/LAP729.html）。正式登记状态请以主管机关档案为准。

https://www.laobiz.com/ip/patent/LAP729.html · CC BY 4.0

数据来源、服务说明与合规信息

数据来源

LaoBiz.com 是面向全球企业的老挝商业信息与市场研究平台，帮助企业更高效地了解老挝市场、发现商业机会并寻找潜在合作伙伴。平台商业信息主要来源于老挝政府主管机关维护的官方公开登记系统，包括工贸部 NED（企业注册）、BNED（经营许可）、eBRS（工商登记）与财政部 TaxRIS（税务登记），以及知识产权等相关官方公开渠道。LaoBiz.com 不创造或修改企业登记事实，而是在上述官方公开信息基础上，通过数据整理、标准化处理、多语言转换、行业分类和智能检索技术，让分散的信息更加易于查询、理解和应用。平台持续关注官方公开数据变化，并通过数据同步机制帮助用户获取企业最新公开状态。

LaoBiz.com is a Laos business-information and market-research platform for global companies—helping users understand the Lao market, discover opportunities and find potential partners more efficiently. Commercial records are drawn mainly from official public registry systems maintained by Lao competent authorities—including MoIC’s NED (enterprise registration), BNED (business licences) and eBRS (business registration), MoF’s TaxRIS (tax registration), and related official public channels such as intellectual-property filings. LaoBiz.com does not create or alter registry facts; on top of those official public records we organise, standardise, translate, classify by industry and index for search so fragmented filings are easier to find, understand and use. We continuously watch official public-data changes and offer sync tools so users can check an enterprise’s latest public status.

LaoBiz.com is a Laos business-information and market-research platform for global companies—helping users understand the Lao market, discover opportunities and find potential partners more efficiently. Commercial records are drawn mainly from official public registry systems maintained by Lao competent authorities—including MoIC’s NED (enterprise registration), BNED (business licences) and eBRS (business registration), MoF’s TaxRIS (tax registration), and related official public channels such as intellectual-property filings. LaoBiz.com does not create or alter registry facts; on top of those official public records we organise, standardise, translate, classify by industry and index for search so fragmented filings are easier to find, understand and use. We continuously watch official public-data changes and offer sync tools so users can check an enterprise’s latest public status.

数据核验与更新

LaoBiz.com 企业详情页提供「同步最新数据」功能。用户可针对指定企业记录主动发起数据核验，平台将根据公开系统返回的信息更新页面展示内容。由于企业登记、税务状态及相关公开信息由不同主管机构维护，数据更新时间可能存在差异。对于商业决策、法律文件、政府审批等正式用途，请以主管机关最新发布的信息及正式文件为准。

Each LaoBiz.com company profile offers “Sync latest data”. Users can actively request verification for a specific enterprise; the page is then refreshed from what the public systems return. Because company registration, tax status and related public filings are maintained by different authorities, update timing may vary. For business decisions, legal documents, government approvals and other formal uses, please rely on the latest information and official documents issued by the competent authority.

Each LaoBiz.com company profile offers “Sync latest data”. Users can actively request verification for a specific enterprise; the page is then refreshed from what the public systems return. Because company registration, tax status and related public filings are maintained by different authorities, update timing may vary. For business decisions, legal documents, government approvals and other formal uses, please rely on the latest information and official documents issued by the competent authority.

平台服务

LaoBiz.com 是独立运营的商业信息服务平台，不属于任何政府机构、登记机关或官方代理机构。平台专注于老挝商业信息整理、企业查询、市场研究和商业数据应用服务，帮助用户完成企业背景查询、行业市场分析、供应链及合作伙伴筛选与投资前期研究。同时，平台可根据用户需求提供老挝市场相关的信息整理、商务咨询及企业服务支持。

LaoBiz.com is an independently operated business information platform and is not a government body, registry office or official agent. We focus on organising Lao commercial information and on company lookup, market research and data-application services—helping users with company background checks, industry analysis, supplier and partner screening, and early-stage investment research. We can also provide Lao-market information support, business advisory and related enterprise services based on user needs.

LaoBiz.com is an independently operated business information platform and is not a government body, registry office or official agent. We focus on organising Lao commercial information and on company lookup, market research and data-application services—helping users with company background checks, industry analysis, supplier and partner screening, and early-stage investment research. We can also provide Lao-market information support, business advisory and related enterprise services based on user needs.

数据权益

老挝政府公开登记信息及相关数据权益归属于对应主管机关。LaoBiz.com 不主张拥有政府原始数据的独占权利，而是提供公开商业信息的整理、检索、多语言展示和应用服务。如权利主体认为相关内容需要修正或调整，可通过平台联系方式提交申请，平台将在核实后进行处理。

Rights in Lao government-published registry information and related data remain with the competent authorities. LaoBiz.com does not claim exclusive ownership of raw government data; we provide organisation, search, multilingual presentation and application of open commercial information. If a rights holder believes content should be corrected or adjusted, please contact us through the site—we will process verified requests.

Rights in Lao government-published registry information and related data remain with the competent authorities. LaoBiz.com does not claim exclusive ownership of raw government data; we provide organisation, search, multilingual presentation and application of open commercial information. If a rights holder believes content should be corrected or adjusted, please contact us through the site—we will process verified requests.

运营主体

LaoBiz.com 由 Shynease Global Holdings Limited（香港，公司编号 80032364）运营。用户条款、订单与付款受中国香港特别行政区法律管辖。法定名称、注册办事处与电话见运营主体信息页。平台整理老挝公开商业信息并提供相关市场服务，遵守适用法律法规及公开信息使用规则。

LaoBiz.com is operated by Shynease Global Holdings Limited (Hong Kong, company no. 80032364). The Terms of Service, orders and payments are governed by the laws of the Hong Kong SAR. Legal name, registered office and phone are on the legal-entity page. We organise Lao public commercial information and related market support, and follow applicable laws and public-information use rules.

LaoBiz.com is operated by Shynease Global Holdings Limited (Hong Kong, company no. 80032364). The Terms of Service, orders and payments are governed by the laws of the Hong Kong SAR. Legal name, registered office and phone are on the legal-entity page. We organise Lao public commercial information and related market support, and follow applicable laws and public-information use rules.

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