PROCESS FOR THE PREPARATION OF A NITRIC OXIDE DONATING PROSTAGLANDIN ANALOGUE
The following summary describes a Laos Patent titled “PROCESS FOR THE PREPARATION OF A NITRIC OXIDE DONATING PROSTAGLANDIN ANALOGUE”, filed by NICOX S.A on 2019-02-12; current status: Registered. Identifiers include application No. P/729; DIP id LAP729; protection kind Patent - PCT National Phase. Key dates: publication 2023-08-25; grant 2023-08-21; expiry reference 2039-02-12. Classification: C07C 201/02、C07C 291/02、C07C 405/00. Inventor(s)/designer(s): ALMIRANTE, Nicoletta. Abstract hint: The present invention relates to a process for preparing the hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-…. Unique application identifiers, holders and classification text are surfaced here to reduce near-duplicate IP landing pages; always verify against the competent office.
P/729
Mark
Key facts
- Type
- Patent
- App. no.
P/729- Status
- Registered
- Applicant
- NICOX S.A
- Agent
- Tilleke & Gibbins Lao Co.,Ltd
- Filing date
- 2019-02-12
- Reg. no.
P/729- Publication
- 2023-08-25
- Registration / grant
- 2023-08-21
- Expiry
- 2039-02-12
- Protection kind
- Patent - PCT National Phase
- Gazette
- 221 · 2023-08-25
- Priority
- FR · 18157888.1 · 2018-02-21
- Applicant address
- NICOX S.A · Drakkar 2-Bat D, 2405 Route des Dolines- CS 10313-Sophia Antipolis, 06560 Valbonne, France · FR
- Agent address
- Tilleke & Gibbins Lao Co.,Ltd · Road, Village, District, Vientiane Capital Lao PDR · LA
- Nice / IPC classes
- C07C 201/02 · C07C 291/02 · C07C 405/00
- Goods / services
- —
Process
Steps follow the current public status-
Filed
-
Formal examination
-
Substantive examination
-
Published
-
Granted
Related records
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Abstract
The present invention relates to a process for preparing the hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]- 3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl ester of formula (I). In accordance with the present invention, the compound (I) can be efficiently prepared with high purity by coupling bimatoprost in a boronate protected form with 6-(nitrooxy)hexanoyl chloride and removing the boronate protecting group. The 6-(nitrooxy)hexanoyl chloride intermediate is prepared by ring-opening reaction of 2-caprolactone and subsequent nitration of the 6-hydroxyhexanoic acid potassium salt with a mixture of HNO 3 and H 2 SO 4 in dichloromethane.
The present invention relates to a process for preparing the hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]- 3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl ester of formula (I). In accordance with the present invention, the compound (I) can be efficiently prepared with high purity by coupling bimatoprost in a boronate protected form with 6-(nitrooxy)hexanoyl chloride and removing the boronate protecting group. The 6-(nitrooxy)hexanoyl chloride intermediate is prepared by ring-opening reaction of 2-caprolactone and subsequent nitration of the 6-hydroxyhexanoic acid potassium salt with a mixture of HNO 3 and H 2 SO 4 in dichloromethane.
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