专利
已注册
IMPROVED PROCESS FOR THE PREPARATION OF TREPROSTINIL AND DERIVATIVES THEREOF
专利「IMPROVED PROCESS FOR THE PREPARATION OF TREPROSTINIL AND DERIVATIVES THEREOF」由 SCIPHARM SARL 持有，当前状态为已注册，申请号 P/337。LaoBiz 老商通提供老挝知识产权信息检索与企业关联查询。
Patent “IMPROVED PROCESS FOR THE PREPARATION OF TREPROSTINIL AND DERIVATIVES THEREOF” is held by SCIPHARM SARL; status: 已注册. Search Laos IP records on LaoBiz.
申请号
P/337
申请日期
2013-05-22
注册/授权日
2023-04-07
申请人
SCIPHARM SARL
代理机构
LAO TRADEMARK AGENCY (LAO IP AGENCY)
类别
C07C 47/565 · C07C 47/575 · C07C 51/377 · C07C 59/72 · C07C 67/29 · C07C 69/18 · C07F 7/18
图样
基础信息
- 类型
- 专利
- 申请号
P/337- 状态
- 已注册
- 申请人
- SCIPHARM SARL
- 代理机构
- LAO TRADEMARK AGENCY (LAO IP AGENCY)
- 申请日期
- 2013-05-22
- 注册号
P/337- 公开/公告日
- 2023-04-07
- 注册/授权日
- 2023-04-07
- 届满日
- 2033-05-22
- 国际分类
- C07C 47/565 · C07C 47/575 · C07C 51/377 · C07C 59/72 · C07C 67/29 · C07C 69/18 · C07F 7/18
- 商品 / 服务
- —
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摘要
A method for the preparation of treprostinil and its derivatives is described. In contrast to prior art, this method utilizes an easily scalable enzymatic resolution of a key intermediate for making these compounds. Another significant improvement of the described method over prior methods is the regioselective Claisen rearrangement of a 5-allyloxy-benzaldehyde precursor, which is facilitated by a bromo subtituent in 2-position.