IMPROVED PROCESS FOR THE PREPARATION OF TREPROSTINIL AND DERIVATIVES THEREOF
LaoBiz.com profiles the Laos Patent “IMPROVED PROCESS FOR THE PREPARATION OF TREPROSTINIL AND DERIVATIVES THEREOF” from open registry fields, filed by SCIPHARM SARL on 2013-05-22; current status: Registered. Identifiers include application No. P/337; DIP id LAP337; protection kind Patent - PCT National Phase. Key dates: publication 2023-04-07; grant 2023-04-07; expiry reference 2033-05-22. Classification: C07C 47/565、C07C 47/575、C07C 51/377、C07C 59/72、C07C 67/29、C07C 69/18、C07F 7/18. Inventor(s)/designer(s): Michael A. MARELLA, Michael P. KIRKUP, Nareshkuma F. JAIN, Sanjeevani A. GHONE. Abstract hint: A method for the preparation of treprostinil and its derivatives is described. In contrast to prior art, this method utilizes an easily sca…. Status labels may change after office actions; refresh or consult primary DIP data before commercial decisions.
P/337
Mark
Key facts
- Type
- Patent
- App. no.
P/337- Status
- Registered
- Applicant
- SCIPHARM SARL
- Agent
- LAO TRADEMARK AGENCY (LAO IP AGENCY)
- Filing date
- 2013-05-22
- Reg. no.
P/337- Publication
- 2023-04-07
- Registration / grant
- 2023-04-07
- Expiry
- 2033-05-22
- Protection kind
- Patent - PCT National Phase
- Gazette
- 201 · 2023-04-07
- Priority
- US · 12172191.4 · 2012-06-15；US · 61/650,836 · 2012-05-23
- Applicant address
- SCIPHARM SARL · 26-28, rue Edward Steichen L-2540 Luxembourg, Luxembourg · LU
- Agent address
- LAO TRADEMARK AGENCY (LAO IP AGENCY) · LLC Bldg, Nongbone Road, Ban Nongbone, Saysettha District, P.O.BOX 925, Vientiane, LAO P.D.R · LA
- Nice / IPC classes
- C07C 47/565 · C07C 47/575 · C07C 51/377 · C07C 59/72 · C07C 67/29 · C07C 69/18 · C07F 7/18
- Goods / services
- —
Process
Steps follow the current public status-
Filed
-
Formal examination
-
Substantive examination
-
Published
-
Granted
Related records
Linked from the LaoBiz.com company databaseSimilar Patent
Abstract
A method for the preparation of treprostinil and its derivatives is described. In contrast to prior art, this method utilizes an easily scalable enzymatic resolution of a key intermediate for making these compounds. Another significant improvement of the described method over prior methods is the regioselective Claisen rearrangement of a 5-allyloxy-benzaldehyde precursor, which is facilitated by a bromo subtituent in 2-position.
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