OLIGONUCLEOTIDE CHELATE COMPLEXES
「OLIGONUCLEOTIDE CHELATE COMPLEXES」对应一条老挝专利公开记录，由 REPLICOR INC. 于 2011-08-18 提交申请，当前状态为已注册。关键编号与类型标注为 申请号 P/239 / DIP 编号 LAP239 / 主管局代码 LA / 保护类型 Patent - PCT National Phase。时间线要点：公开/公告日 2023-03-24；授权日 2023-03-24；届满/失效参考日 2031-08-18。技术或外观分类记载为 A61K 21/00、A61K 31/7088、A61K 31/712、A61K 31/7125、A61K 31/713、A61K 47/02。发明人 / 设计人包括 Andrew VAILLANT、Michel BAZINET。代理机构 / 代理人记载为 Lao Trademark Agency。公开摘要提示：The present disclosure describes the broadly active chelation of divalent 2+ metal cations by any oligonucleotide(ON), re-gardless of size…。
P/239
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基础信息
- 类型
- 专利
- 申请号
P/239- 状态
- 已注册
- 申请人
- REPLICOR INC.
- 代理机构
- Lao Trademark Agency
- 申请日期
- 2011-08-18
- 注册号
P/239- 公开 / 公告日
- 2023-03-24
- 注册 / 授权日
- 2023-03-24
- 到期日
- 2031-08-18
- 国际分类
- A61K 21/00 · A61K 31/7088 · A61K 31/712 · A61K 31/7125 · A61K 31/713 · A61K 47/02
- 商品 / 服务
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摘要
The present disclosure describes the broadly active chelation of divalent 2+ metal cations by any oligonucleotide(ON), re-gardless of size or modifiantion. This chelation effect is specific to cations which are divalent (or of higher valency) and results in the formation of oligonucleotide chelate complexes which do not behave like salts. It is described herein a novel composition of an ON chelate complex prepared using any ON and a divalent metal cation and methods for the suppression of anti-coagulation and or subcutaneous injection site reactions and or improved tolerability with oligonucleotides by the use of ON chelate complexes during oligonucleotide administration.
The present disclosure describes the broadly active chelation of divalent 2+ metal cations by any oligonucleotide(ON), re-gardless of size or modifiantion. This chelation effect is specific to cations which are divalent (or of higher valency) and results in the formation of oligonucleotide chelate complexes which do not behave like salts. It is described herein a novel composition of an ON chelate complex prepared using any ON and a divalent metal cation and methods for the suppression of anti-coagulation and or subcutaneous injection site reactions and or improved tolerability with oligonucleotides by the use of ON chelate complexes during oligonucleotide administration.
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